Science Direct Topics: Low Dose Statin List

Thursday, November 19, 2020

Low Dose Statin List

Some statins particularly those metabolized by CYP 3A4 such as atorvastatin pravastatin and simvastatin can interact with several other drugs such as clarithromycin protease inhibitors cyclosporine gemfibrozil oral contraceptives and digoxin. Statin Moderate Daily Adult Dose Providing Similar Average LDL-Loweringbased on reference 1 unless otherwise denoted Low-intensity expected LDL reduction.

Acc Aha Release Updated Guideline On The Treatment Of Blood Cholesterol To Reduce Ascvd Risk Practice Guidelines American Family Physician

Trade Name Generic Name.

Low dose statin list. For a complete list of severe side effects please refer to the individual drug monographs. Cerivastatin withdrawn 2001 The Baycol Disaster. Low-Intensity lowers LDL-C 30 10mg.

Low-density lipoprotein LDL cholesterol. 22 br 24 40mg 95 gen 150 br 20 10 mg 4 gen 43 br 19 gen 58 br 20mg 95 gen 150 br 18. Rhabdomyolysis can cause severe muscle pain liver damage kidney failure and death.

Initiate with a lower dose and avoid very high dose or high intensity statins if at increased risk of myotoxicity eg. 433 It is also recommended that simvastatin not exceed 20 mg when used with amlodipine but a lower dose. Statins are a class of drugs that lower LDL or bad cholesterol levels in the body by preventing production in the liver where the majority of the READ MORE 6 Tips for Reducing Your.

In comparison with the simvastatin-only group those taking simvastatin plus ezetimibe had an LDL cholesterol level 16 mgdL lower and a 64 P0016 lower risk of having a major cardiovascular event but there was no significant effect on all-cause death. The shading reflects doses listed in the ACCAHA Guideline on Treatment of Blood Cholesterol 2013 as reflecting high-intensity therapy 50. Most people should try to keep their total cholesterol below 200 milligrams per deciliter mgdL or 52 millimoles per liter mmolL.

Lovastatin with Niacin Advicor Side Effects. 3335 Based on AEs reported in the literature a maximum daily dosage of 20 mg for lovastatin is recommended when used with amlodipine diltiazem or verapamil. 1 and millions of patients the world over now on a statin statin myopathy is now running at epidemic levels.

The 80 mg dose should be considered only in patients with severe hypercholesterolaemia and high risk of cardiovascular complications who have not achieved their treatment goals on lower doses when the benefits are expected to outweigh the potential risks. With the incidence of statin-associated myopathy by some estimates at 12-15 Ref. Based on their lipid-lowering drug treatments they were divided into the following two groups.

Side effects reported by some people include muscle pain and digestive problems. Side effects drug interactions and patient information is also provided. Read about statins cholesterol lowering medications like Levacor Zocor Pravachol Lipitor Crestor and more.

26 5 mg 4 g 82 br 20 mg 4 gen 43. Aim to keep this bad cholesterol under 100 mgdL or 26 mmolL. 5 The FOURIER trial Further Cardiovascular Outcomes Research with PCSK9 Inhibition in Subjects with Elevated Risk compared the effects of statin alone with those of statin.

The drugs that doctors use to treat the new disease are called statinssold under a variety of names including Lipitor atorvastatin Zocor simvastatin Mevacor. The study defined low -intensity statin therapy as treatment with fluvastatin 20 to 40 mg lovastatin 20 mg simvastatin 10 mg pitavastatin 1. Statin drugs listed by trade name and generic name plus internal site links to statin drug related pages.

This eMedTV segment provides a complete list of all statin drugs that are available in the United States at this time and offers links to specific information. Muscle pain is the most common side effect caused by statin use. Statins are commonly used to treat high cholesterol and prevent related health conditions.

Today it is almost standard that the starting dose be at least 20 to 40 mg of atorvastatin Lipitor or simvastatin Zocor - or its equivalent in the other statins. Rhabdomyolysis can occur when you take statins in combination with certain drugs or if you take a high dose of statins. Similarly to amiodarone amlodipine diltiazem and verapamil inhibit CYP3A4.

Common side effects of all statins. 3335-37 Amlodipine also has an inhibitory effect on Pgp. The elderly severe renal impairment eGFR.

There is an increased risk of myopathy associated with high dose 80 mg simvastatin. 26 patients were allocated to the intensive statin group among them 20 patients received rosuvastatin 20 mg or atorvastatin 40 mg four reduced their rosuvastatin dose from 20 mg to 15 mg and two lowered their atorvastatin dose from 40 mg to 30 mg after 13 months owing to myalgia caused by a higher dose of statin. The team looked at the impact of the statin therapy and the dose of medication on the incidence of death in the study population over one year.

The risk of very serious side effects is extremely low and calculated in a few cases per million people taking statins.

Definitions Of Low Moderate And High Dose Statins Download Table